Jan 01, 2001 however, inhibition of free radical pathways would not be the mechanism of the antimutagenic action exerted by fluphenazine against the simple alkylating agent, mms. The antimutagenic activity of spearmint mentha spicata, a popular food flavoring agent, was studied in the salmonella assay. Antioxidant and antimutagenic activity of 2carboxyethylchitosan. Microbialodemethylation of sinesetin and antimutagenic activity of the metabolite. The mucilage polysaccharide was extracted from dioscorea opposita in cold water and then degraded in two reagents hydrogen peroxide and ascorbic acid. Assessment of the antioxidant and antimutagenic activity of extracts from goji berry of greek cultivation. Comparison of polyphenol profile and antimutagenic and. The degradation, antioxidant and antimutagenic activity of the mucilage polysaccharide from dioscorea opposita. In vitro antimutagenic activity of eclipta alba using ames. Fluphenazine fph exhibited antimutagenic activity in lymphocyte cultures, markedly decreasing genotoxic effects of standard mutagenic agents present in cell cultures. Antimutagenic activity was detected in fractions 16 to 40 for r11, 27 to 39 for r12, and 23 to 33 for r2. Dec 18, 2019 the antibacterial and antifungal activity of the polymeric microspheres were evaluated by well. Arjunolic acid was the only compound with good antioxidant activity and had better antimutagenic activity than eicosanoic acid and n.
Antimutagenic activity of unfermented milk made from both strains was attributed to the bacterial cells, and the activity was stable during. There was a direct correlation between the presence of antioxidant activity and antimutagenic activity of the plant extracts. The mutagenic and antimutagenic activities of hexane, chloroform, ethyl acetate and methanol extracts from leaves of myrtus communis, were investigated by. The chemically complex nature of these medicinal preparations results in a significant increased risk of toxicity, including genotoxicity. Potential antimutagenic activity of berberine, a constituent. Further, the comparison of antimutagenic activity and antioxidant. No clear relationship was found between chemical profiles and antimutagenic activity. Citeseerx antimutagenic activity of new analogues of. Antimutagenic activity of lipidovit depended on the scheme of treatment. Pdf antioxidative and antimutagenic activity of yeast cell. Antimutagenic activity an overview sciencedirect topics. Some doseresponse effects on mutagen activationflavonoid interactions, mutation research genetic toxicology and environmental mutagenesis on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Antimutagenic activity of flavonoids from chrysanthemum. The protective effects in posttreatment may be due to stimulation of repair andor reversion of dna damage. Structure analysis and antimutagenic activity of a novel salt. Study of interaction of antimutagenic 1,4dihydropyridine. Pdf assessment of the antioxidant and antimutagenic.
Three glycoproteins with antimutagenic activity identified. Phytochemical investigation and evaluation of antimutagenic activity of the extract of cuscuta reflexa roxb by ames test sudheer kumar dokuparthi 1, nilanjana banerjee 2, ashish kumar 3, venogopal singamaneni 1, ashok kumar giri 2 and sibabrata mukhopadhyay3. Antimutagenic activity can be affected by a variety of factors such as chemical andor enzymatic inactivation, scavenging of reactive oxygen species ros or prevention of the formation of mutagenic metabolites. To determine if antioxidants in the fruits contribute to the antimutagenic activity observed, a solution of ascorbic acid was prepared to obtain a ph equivalent to that. The bark and leaves of the plant were reported to have biological activities including antipyretic, antimalarial, and antioxidative due to the abundance of secondary metabolites. The antimutagenic activities of the cell bodies of several lab isolated from kimchi were studied using the ames test and. Antimutagenic activities of some foods, journal of the. Antibacterial and antimutagenic activitiy of extracts and. The suppressive compounds were mainly localized in the ethyl acetate extract fraction. Desmutagenic and bioantimutagenic activity of docosahexaenoic acid and eicosapentaenoic acid in cultured chinese hamster v79 cells. The antimutagenic property of three of the selected plants has not previously reported. Compound 1 and its related analogues were examined for their antimutagenic activity against mutations induced by ethyl. As part of a study aimed at developing new pharmaceutical products from natural resources, the purpose of this research was twofold. Antimutagenic activity of chemical fractions isolated from a commercial soybean processing byproduct michael jacob plewa, elizabeth d.
Antimutagenic activity of gigantol from dendrobium nobile. Antimutagenic components in spatholobus suberectus dunn. The over all antimutagenic potential of above four extracts was found to be in order of a. Antimutagenic activity of some saponins isolated from. Antimutagenic activity of polymethoxyflavonoids from citrus. Mar 11, 2014 moreover, the antimutagenic activity of a powder of grain lisosan g in yeast saccharomyces cerevisiae was attributed primarily to the antioxidant potency of lisosan g polyphenols frassinetti et al. The suppressive compounds were mainly localized in the ethyl acetate extract. Antitumorpromotion and growth inhibition of tumors or tumor cell lines were reported. Chukrasia tabularis a juss belonging to family meliaceae is commonly known as chickrassy, lal devdari, chittgong wood.
A total of 8 medicinal plant preparations used in the philippines have been examined for. Materials and methods bacterial strains and chemicalssalmonella. Several food groups, including raspberries, strawberries, grapes, pecans, and walnuts, are rich in ellagitannins, but these vary in the relative amounts of the complex polyphenolic. The aim of the present work was to assess the antioxidative and antimutagenic activity of glucomannan and proteinglucomannan isolated from c. Antimutagenic, antioxidant and free radical scavenging. There are few studies that investigated the antimutagenic activity of soybean extracts or saponins. Antioxidative and antimutagenic activity of yeast cell wall mannans in vitro. Antimutagenic and antioxidant characteristics of chukrasia. Fruits and vegetables as dietary sources of antimutagens united. Antioxidant, mutagenic, and antimutagenic activity of. Antimutagenic activity of chemical fractions isolated from. In vitro mutagenic, antimutagenic, and antioxidant activities.
Thus, a search for mechanisms of fluphenazines antimutagenic activity. In vitro mutagenic, antimutagenic, and antioxidant potency evaluation and biotransformation of six novel 4. Ethyl methane sulfonate antimutagenic activity human diploid cell methyl methane sulfonate ethyl methane. Mutagenic and antimutagenic activities in philippine. Read antioxidative and antimutagenic activity of yeast cell wall mannans in vitro, mutation research genetic toxicology and environmental mutagenesis on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. The antimutagenic properties of all compounds were also examined against sodium azide in human lymphocyte cells by micronuclei and sister chromatid exchange tests. Antioxidative and antimutagenic activity of yeast cell. The correlation between antimutagenic activity and total. Antimutagenic activities of some foods antimutagenic activities of some foods karakaya, sibel. Auricularia polytricha is known to be a highly nutritious foodstuff. Most samples 74% showed antioxidant activity similar to vitamin c in the dpph. The isolated compounds suppressed the expression of the umu gene following the induction of sos response in the salmonella typhimurium ta1535psk1002 that have been treated with various mutagens. Moreover, the antimutagenic activity of a powder of grain lisosan g in yeast saccharomyces cerevisiae was attributed primarily to the antioxidant potency of lisosan g polyphenols frassinetti et al. Thus, a search for mechanisms of fluphenazines antimutagenic activity, besides the antifree radical action, has been undertaken.
It was maximum during pretreatment of animals 5 day or administration in. In this study, antimutagenic activity of methanolic extracts of above four plants using ames salmonella test assay against two direct acting mutagens has been reported. Pdf antimutagenic activity of olive leaf aqueous extract by ames. However, the strong pharmacological activity of this neuroleptic drug, together with its serious side effects on the central nervous system. Phenylpropanoids that possess antimutagenic activity were isolated from the buds of clove syzygium aromaticum. The mutagenic and antimutagenic activity of sutherlandia. Antimutagenic activity of vitamins in cultured mammalian cells. The present study confirms the strong antimutagenic, preventive, and restorative effects of cnsl. Antimutagenic activity of fluphenazine in shortterm tests. Read the antimutagenic activity of the major flavonoids of rooibos aspalathus linearis. Three lowmolecularweightsamples were prepared, and their antioxidant and antimutagenic activity were investigated. However, inhibition of free radical pathways would not be the mechanism of the antimutagenic action exerted by fluphenazine against the simple alkylating agent, mms. Spearmint leaves were brewed in hot water for 5 min at concentrations up to 5% wv, and the water extracts were tested against the direct.
Antimutagenic activity of methanolic extracts of four. The degradation, antioxidant and antimutagenic activity of. A methanol extract from dendrobium nobile showed a suppressive effect on umu gene expression of the sos response in salmonella typhimurium ta1535psk1002 against the mutagen 22furyl35nitro2furylacrylamide furylfuramide. The antimutagenic activity of two plants maytenus ilicifolia and peltastes peltatus, both rich in compounds of the flavonoid and tannin groups and frequently employed in folk medicine, was studied. The aim of the current study was to test the capability of the compound to scavenge peroxynitrite and hydroxyl radical, to test intracellular.
Antimutagenic activity of isoflavones from soybean seeds glycine max merrill. The differents antimutagenic activity of chl than ea and pe extracts could be explained by the antioxidant activity is often the result of the. The results indicate that caj and cajuina have mutagenic, radical. Citeseerx document details isaac councill, lee giles, pradeep teregowda. Trpp1, which require livermetabolizing enzymes, and uv irradiation. Antimutagenic activity of spearmint, environmental and. Antimutagenic activity of berry extracts 451 of dna, and stimulation of glutathionestransferase activity, resulting in activation of detoxification pathways. In conclusion, both species have diverse activity and their phytochemical profiles should be considered in quality evaluation.
Mitsuo miyazawa, yoshiharu okuno, seiichi nakamura, and, hiromu kameoka. Probiotic strains also exert antimutagenic activity due to their potential to bind mutagenic substances on the cell surface raman et al. Each fraction possessing antimutagenic activity was pooled and used as purified r11, r12, and r2 fractions for the characterization of the substances. Pdf antioxidant, mutagenic, and antimutagenic activity. Antimutagenic compounds and their possible mechanisms of action. The isolated compounds had varying antimutagenic activity, antioxidant activity and did not have substantial toxicity towards human liver cells c3a cell line. Mutagenic and antimutagenic evaluations were performed in eukaryotic cells of saccharomyces cerevisiae yeast. Antimutagenic activity of phenylpropanoids from clove. Antimutagenic and free radical scavenger effects of leaf.
The ames test revealed no mutagenic activity using the salmonella typhimurium strains ta98, ta100 and ta102. The possible mechanism of the antimutagenic activity of saponins is discussed. The degradation, antioxidant and antimutagenic activity of the. Up of these weeds can also provide potential chemopreventive substances for further studies. Antimutagenic activity of isoflavone from pueraria lobata. The search for synthetic antimutagens is another important trend in the area of antimutagenicity research. Background 1,4dihydropyridines 1,4dhp possesses important biochemical and pharmacological properties, including antioxidant and antimutagenic activities. Dose dependent antimutagenic activity of the extracts is also evident from linear regression analysis of the data. In this study the ea extract which showed superior antioxidant activity also demonstrated better antimutagenic activity. Characterization and antimutagenic activity of soybean saponins. Mutation research genetic toxicology and environmental mutagenesis. The aim of the current study was to evaluate antimutagenic potential of ethanolic extract of eclipta alba eeea. It was shown that the antimutagenic 1,4dihydropyridine av153na interacts with dna.
The antibacterial and antifungal activity of the polymeric microspheres were evaluated by well. Therefore we have selected the rhizome of this plant and evaluated the antioxidant and antimutagenic activity of some of the selected extracts against. The antimutagenic activity of spearmint mentha spicata, a popular food flavoring agent. Comparison of polyphenol profile and antimutagenic and antioxidant activities in two species used as source of. A marked inhibitory effect was observed against salmonella typhimurium, whereas lower activity was observed against. Aqueous and flavonoidenriched extract as well as essential oil eo obtained from leaves of pistacia lentiscus were assessed for antibacterial and antimutagenic activities. Antimutagenic and antioxidant activity of the essential oils. In this study raw and boiled juice and leaf and dried seeds of urtica sp, stachys annula, sage, rosehip, grape molasses and. But the antimutagenic activity of onion extracts is. Rat liver extract is added to activate the indirect acting.
Mutagenicity, antioxidant potential, and antimutagenic. Characterization and antimutagenic activity of soybean. For the in vitro ames test, two strains of salmonella typhimurium ta 98 and ta 1535 were used in the presence and absence of rat liver. Pdf antioxidative and antimutagenic activity of yeast. Antimutagenic properties of lipidovit produced from the biomass of blakeslea trispora fungi was studied by its effect on induction of chromosome aberrations by chemical mutagens dioxidine and cyclophosphamide in mouse bone marrow cells. Antimutagenic activity was increased significantly when there were s9. Download fulltext pdf antimutagenic activity of berry extracts article pdf available in journal of medicinal food 74.
The methanol extract from citrus aurantium showed a suppressive effect on umu gene expression of sos response in salmonella typhimurium ta1535psk1002 against the mutagen 22furyl35nitro2furylacrylamide furylfuramide. Antimutagenic activity of polymethoxyflavonoids from. However, fraction pcc100tlc3 exhibited the strongest antimutagenic activity against 2aaaf, and was not different from the control. A major mechanism of the anticarcinogenic activity of tea in animals is impairment of the interaction of carcinogens with dna leading to mutations. Structure analysis and antimutagenic activity of a novel. The hepatoprotective and antioxidant activity of e. In vitro antioxidant, antimutagenic and genoprotective. Analysis of plant extracts antimutagenicity using the ames test and. Sep, 2017 the essential oils of citrus sinensis and citrus latifolia showed antimycotic activity against candida spp. Antimutagenic compounds and their possible mechanisms of. The aim of this study was to identify the antimutagenic components from extracts of s. Request pdf antimutagenic activity of isoflavone from pueraria lobata a methanol extract from pueraria lobata showed a suppressive effect on umu gene expression of the sos response in. In addition to the antimutagenic activities of these compounds against furylfuramide, trpp1 and activated trpp1 were also assayed by the ames test using s.
Pdf download for analysis of plant extracts antimutagenicity using the. Antimutagenicity was determined against known mutagenic substances 4oxide1nitroquinoline, sodium azide, 2nitrofluorene, aflatoxin b 1, 2. Antimutagenic definition, capable of reducing the frequency of mutation. Antimutagenic activity of flavonoids from pogostemon cablin. These activities may constitute the main factor accounting for the antimutagenic activity exhibited by these compounds. Journal of agricultural and food chemistry 1999, 47 4, 4649. Antimutagenic, antioxidant and free radical scavenging activity of ethyl acetate extracts from white, yellow and red onions. Similarly, antimutagenic activity of compounds against induced mutations can also be evaluated 64. Found to perform antimutagenic activity through the increase of ogg1 expression, which is an enzyme responsible to remove 8oxoguanine a mutagenic product created after cells exposure to oxidative stress. Antimutagenic activity of extracts of natural substances in. Antioxidant and antimutagenic activity of curcuma caesia roxb.
Antimutagenic activity of extracts of natural substances in the. Antibacterial activity of different extracts and eo were evaluated against six bacterial strains. Antimutagenic and free radical scavenger effects of leaf extracts from accacia salicina. Correlation between flavonoid content and the no production inhibitory activity of peel extracts from various citrus fruits.
We report here the purification, structure characterization and antimutagenic activity in vivo of a 0. Antimutagenic activity of flavonoids from chrysanthemum morifolium. Abstractin developing countries there is increasing interest and research in the area of herbal medicines as an approach to reducing costs of health care. Antioxidative and antimutagenic activity of yeast cell wall. The antimutagenic activity of two plants maytenus ilicifolia and peltastes peltatus, both rich in compounds of the flavonoid and tannin groups. A significant antimutagenic effect of the extract was observed against the metabolic activated mutagens 2. These also help in biotransformation and purification of procarcinogens and cancercausing substances into less poisonous metabolites, and in this way the probiotics help prevent cancer formation poolzobel et al. Desmutagenic and bio antimutagenic activity of docosahexaenoic acid and eicosapentaenoic acid in cultured chinese hamster v79 cells. Pdf antioxidant, mutagenic, and antimutagenic activity of. The correlation between antimutagenic activity and total phenolic. Saponins have antiviral activity against hiv, cholesterol level lowering activity, and antioxidative activity. Increase of single break repair by rejoining and induction of genes related to base and nucleotide excision. Three glycoproteins with antimutagenic activity identified in. Antioxidant and antimutagenic activity of curcuma caesia.
1242 966 777 567 966 1331 1160 579 746 1337 1192 1003 1277 765 1305 1399 116 658 271 1476 1177 875 1125 98 359 835 708 844 4 824 1037 1192 198 853 1369 533 705 92